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AQA GCSE Biology

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Theme 1: Cell Biology

Cell Structure (7 lessons)

Explore cell structure in Biology.

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Eukaryotes and Prokaryotes

Learn how eukaryotic and prokaryotic cells differ, and measure tiny cells using standard form.

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Animal and Plant Cells

Learn what each part of animal, plant and bacterial cells does, and compare their sizes.

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Specialised Cells and Differentiation

How sperm, nerve, muscle and plant cells are built for their jobs, and how cells differentiate.

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Microscopes and Magnification

How microscopes developed, light versus electron microscopes, and calculating magnification, image size and real size.

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Required Practical: Looking at Cells Under a Microscope

Prepare, stain and focus slides of plant and animal cells, then draw and label them.

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Culturing Microorganisms

Grow bacteria safely using aseptic technique, then calculate population size and colony area.

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Required Practical: Antibiotics and Bacterial Growth

Test antibiotics and antiseptics on bacteria, measure zones of inhibition and calculate their areas.

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Cell Division (2 lessons)

Explore cell division in Biology.

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Chromosomes, Mitosis and the Cell Cycle

Chromosomes, genes and DNA, then the three stages of the cell cycle including mitosis.

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Stem Cells

What stem cells are, where they are found, medical uses, risks, ethics, and plant cloning.

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Transport in Cells (5 lessons)

Explore transport in cells in Biology.

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Diffusion

How substances move in and out of cells by diffusion, and what makes it faster.

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Surface Area to Volume Ratio and Exchange Surfaces

Why large organisms need exchange surfaces, and how surface area to volume ratios compare

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Osmosis

How water moves across cell membranes by osmosis, and how to measure and graph it

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Required Practical: Osmosis in Plant Tissue

How to investigate osmosis in potato cylinders, process the results and evaluate the method

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Active Transport

How active transport moves substances against a gradient using energy from respiration

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Theme 2: Organisation

Principles of Organisation (1 lessons)

Explore principles of organisation in Biology.

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Cells, Tissues, Organs and Systems

Learn how cells, tissues, organs and organ systems fit together, using the digestive system.

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Animal Tissues, Organs and Systems (11 lessons)

Explore animal tissues, organs and systems in Biology.

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Enzymes and the Lock and Key Model

Learn what enzymes are, how the lock and key model works, and how to calculate rates.

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Digestive Enzymes and Bile

How amylase, proteases, lipases and bile break food into small molecules the body can absorb.

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Required Practical: Food Tests

Learn how to test foods for sugars, starch, protein and lipids using colour-change reagents.

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Required Practical: pH and the Rate of Amylase Activity

Investigate how pH affects amylase using iodine sampling, rate calculations, graphs and error analysis.

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The Heart

How the heart pumps blood in a double circulatory system, its chambers, vessels and pacemakers.

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Blood Vessels and the Lungs

How arteries, veins and capillaries suit their jobs, blood flow rates, and gas exchange in lungs.

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Blood

Blood as a tissue: plasma, red and white blood cells and platelets, their jobs and adaptations.

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Coronary Heart Disease and Its Treatments

Coronary heart disease, stents, statins, faulty valves, transplants, artificial hearts and evaluating treatments.

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Health and Disease

Health, how diseases interact, reading disease data in charts, and why sampling matters

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Lifestyle and Non-Communicable Diseases

Risk factors for non-communicable disease: diet, smoking, alcohol, carcinogens, costs and reading risk data

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Cancer

Cancer as uncontrolled cell growth, benign and malignant tumours, and lifestyle and genetic risk factors

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Plant Tissues, Organs and Systems (3 lessons)

Explore plant tissues, organs and systems in Biology.

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Plant Tissues and the Leaf

How plant tissues suit their jobs and how they fit together to build the leaf.

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Transpiration and Translocation

How plants move water, mineral ions and sugars: root hairs, xylem, phloem and stomata.

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Measuring the Rate of Transpiration

How temperature, humidity, air movement and light affect transpiration, and how to measure and analyse it.

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Theme 3: Infection and Response

Communicable Diseases (7 lessons)

Explore communicable diseases in Biology.

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Pathogens and How Disease Spreads

What pathogens are, how they spread, how they cause illness and how spread is reduced.

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Viral Diseases

Measles, HIV and AIDS, and tobacco mosaic virus: symptoms, spread and effects.

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Bacterial, Fungal and Protist Diseases

Salmonella, gonorrhoea, rose black spot and malaria: how they spread, symptoms and control.

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Human Defence Systems

How skin, nose, airways and stomach block pathogens, and how white blood cells fight them.

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Vaccination

How vaccines prepare white blood cells, protect individuals, and give whole populations herd immunity.

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Antibiotics and Painkillers

How antibiotics kill bacteria, why they fail against viruses, and what painkillers do.

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Discovering and Developing New Drugs

How new medicines are discovered, tested in the lab, trialled on people and peer reviewed.

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Monoclonal Antibodies (1 lessons)

Explore monoclonal antibodies in Biology.

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Monoclonal Antibodies

How monoclonal antibodies are made from hybridoma cells and used in tests, research and cancer treatment.

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Plant Disease (1 lessons)

Explore plant disease in Biology.

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Plant Disease and Defence

How plant disease is detected, ion deficiencies, and plant defence responses.

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Theme 4: Bioenergetics

Photosynthesis (4 lessons)

Explore photosynthesis in Biology.

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Photosynthesis and the Uses of Glucose

Learn the photosynthesis equation, why it is endothermic, and how plants use glucose.

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Rate of Photosynthesis

Learn how temperature, light, carbon dioxide and chlorophyll change photosynthesis rate, and read rate graphs.

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Limiting Factors and Greenhouses

Explain graphs with several limiting factors, the inverse square law for light, and greenhouse economics.

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Required Practical: Light Intensity and Photosynthesis

Plan and run the pondweed investigation into how light intensity changes the rate of photosynthesis.

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Respiration (3 lessons)

Explore respiration in Biology.

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Aerobic and Anaerobic Respiration

Learn how cells transfer energy by aerobic and anaerobic respiration, with equations and fermentation in yeast.

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Response to Exercise

How exercise changes heart rate and breathing, and why lactic acid and oxygen debt build up.

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Metabolism

How cells use energy to build and break down carbohydrates, lipids and proteins, including urea.

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Theme 5: Homeostasis and Response

Homeostasis (1 lessons)

Explore homeostasis in Biology.

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Homeostasis and Control Systems

How the body keeps internal conditions steady using receptors, coordination centres and effectors.

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The Human Nervous System (5 lessons)

Explore the human nervous system in Biology.

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The Nervous System and Reflexes

How neurones, the CNS and effectors produce responses, and how reflex arcs work.

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Required Practical: Reaction Time

How to plan and run the ruler drop reaction time investigation, with repeats, means and graphs

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The Brain

Learn the brain's main regions, what each controls, and how scientists map and treat it.

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The Eye

Learn the eye's structures, how it focuses, and how sight defects are corrected.

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Controlling Body Temperature

How the brain, skin receptors, blood vessels, sweat glands and muscles keep body temperature steady.

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Hormonal Coordination in Humans (9 lessons)

Explore hormonal coordination in humans in Biology.

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The Endocrine System

How glands release hormones into the blood to coordinate the body, and where they are.

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Controlling Blood Glucose

How the pancreas uses insulin to control blood glucose, and how glucagon helps at Higher tier.

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Diabetes

The two types of diabetes, how each is treated, obesity risk and glucose graphs.

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Water Balance and the Kidneys

How the kidneys keep water balance, make urine and, at higher tier, how ADH works.

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Kidney Failure: Dialysis and Transplants

How dialysis cleans the blood, how a kidney transplant works, and weighing up each treatment.

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Hormones in Human Reproduction

How reproductive hormones control puberty, egg release and the menstrual cycle in humans.

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Contraception

How hormonal and non-hormonal contraception works, and how to evaluate each method.

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Hormones and Infertility Treatment

How hormones are used to treat infertility, including the steps and drawbacks of IVF.

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Adrenaline, Thyroxine and Negative Feedback

How adrenaline prepares the body for fight or flight and how negative feedback controls thyroxine.

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Plant Hormones (3 lessons)

Explore plant hormones in Biology.

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Plant Hormones and Tropisms

Learn how auxin makes shoots bend to light and roots grow down.

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Required Practical: Light, Gravity and Seedling Growth

Plan and carry out an investigation into how light or gravity affects seedling growth.

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Using Plant Hormones

Learn how auxins, ethene and gibberellins are used in farming, and how weed killers affect biodiversity.

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Theme 6: Inheritance, Variation and Evolution

Reproduction (10 lessons)

Explore reproduction in Biology.

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Sexual and Asexual Reproduction

Compare sexual and asexual reproduction: gametes, fusion, variety, clones, and meiosis versus mitosis.

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Meiosis

How meiosis makes four different gametes with half the chromosomes and fertilisation restores the full number.

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Pros and Cons of Sexual and Asexual Reproduction

Advantages of sexual and asexual reproduction, and organisms that use both methods.

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DNA and the Genome

Learn the double helix structure of DNA, genes, the genome and why the human genome matters.

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DNA Structure

How DNA is built from four nucleotides and how three bases code for amino acids

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Protein Synthesis and Mutations

How proteins are made on ribosomes, fold into shape, and how mutations change them

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Genes, Alleles and Inheritance

Alleles, genotype and phenotype, dominant and recessive alleles, homozygous and heterozygous, and multiple genes

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Punnett Squares and Genetic Crosses

Complete Punnett squares, predict genetic cross outcomes as ratios and probabilities, and read family trees.

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Inherited Disorders and Embryo Screening

Learn how alleles cause polydactyly and cystic fibrosis, and weigh up the issues of embryo screening.

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Sex Determination

Learn how sex chromosomes XX and XY decide sex and show it in a genetic cross.

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Variation and Evolution (5 lessons)

Explore variation and evolution in Biology.

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Variation

How genes and the environment cause variation, and how mutations produce new phenotypes.

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Evolution by Natural Selection

What evolution is, how natural selection works and how new species form.

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Selective Breeding

How humans breed plants and animals for useful traits, plus the benefits, risks and ethics.

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Genetic Engineering

How genes are moved between organisms, with GM crops, insulin, benefits, risks and objections.

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Cloning

Learn how plants and animals are cloned and the benefits, risks and ethics of cloning.

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Understanding Genetics and Evolution (5 lessons)

Explore understanding genetics and evolution in Biology.

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Darwin, Lamarck and the Theory of Evolution

Learn how Darwin developed his theory, why it was resisted, and why Lamarck's idea is rejected.

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Wallace and Speciation

Learn what Wallace added to evolution theory and the steps that form new species.

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Mendel and the Discovery of Genes

How Mendel's plant experiments, chromosomes and DNA built up our understanding of genes.

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Evidence for Evolution and Fossils

Learn the evidence for evolution, how fossils form, and why the fossil record is incomplete.

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Extinction and Resistant Bacteria

Learn what causes extinction and how antibiotic resistant bacteria such as MRSA arise and spread.

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Classification (1 lessons)

Explore classification in Biology.

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Classification of Living Organisms

Learn the Linnaean system, binomial names, the three-domain system and how to read evolutionary trees.

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Theme 7: Ecology

Adaptations, Interdependence and Competition (3 lessons)

Explore adaptations, interdependence and competition in Biology.

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Ecosystems, Communities and Competition

Learn how living things are organised in ecosystems and how competition and interdependence shape communities.

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Abiotic and Biotic Factors

Learn the non-living and living factors that affect communities, and how to explain and interpret changes.

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Adaptations

Learn how structural, behavioural and functional adaptations help organisms survive, and meet extremophiles in extreme environments.

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Organisation of an Ecosystem (7 lessons)

Explore organisation of an ecosystem in Biology.

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Food Chains and Predator-Prey Cycles

Learn how food chains start with producers and why predator and prey numbers cycle.

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Sampling with Quadrats and Transects

Use quadrats and transects to sample species, then calculate means, modes and medians and plot graphs.

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Required Practical: Measuring Population Size

Estimate a population with quadrats and use a transect to test how light affects distribution

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The Carbon and Water Cycles

How carbon and water cycle through ecosystems and how microorganisms return carbon dioxide and mineral ions

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Decomposition

How temperature, water and oxygen change the rate of decay, plus compost, methane and biogas.

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Required Practical: Temperature and the Rate of Decay

Investigate how temperature affects the rate of decay of milk using pH change.

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Environmental Change and Species Distribution

How temperature, water and atmospheric gases change where species live, and how to evaluate it.

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Biodiversity and Human Impact (3 lessons)

Explore biodiversity and human impact in Biology.

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Biodiversity and Waste Management

Learn what biodiversity is, why it matters, and how waste and pollution reduce it.

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Land Use, Deforestation and Global Warming

Learn how land use, peat destruction and deforestation reduce biodiversity and contribute to global warming.

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Maintaining Biodiversity

Learn the programmes that protect biodiversity and why people disagree about how to use land.

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Trophic Levels in an Ecosystem (2 lessons)

Explore trophic levels in an ecosystem in Biology.

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Trophic Levels and Pyramids of Biomass

Number the trophic levels in a food chain and draw accurate pyramids of biomass.

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Transfer of Biomass

Explain why biomass falls at each trophic level and calculate the efficiency of biomass transfer.

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Food Production (2 lessons)

Explore food production in Biology.

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Food Security and Farming Techniques

Explain what food security is, what threatens it, and how intensive farming raises efficiency.

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Sustainable Fisheries and Biotechnology

Explain how fisheries are kept sustainable and how biotechnology and GM help feed people.

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Theme 8: Working Scientifically

Scientific Thinking (1 lessons)

Explore scientific thinking in Biology.

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How Science Works

How scientific ideas change, how models work, weighing risk and ethics, and why peer review matters.

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Experimental Skills (1 lessons)

Explore experimental skills in Biology.

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Planning Experiments and Variables

Writing hypotheses, planning fair tests, controlling variables, working safely, sampling and evaluating methods.

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Analysing and Evaluating Data (2 lessons)

Explore analysing and evaluating data in Biology.

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Presenting and Processing Data

Presenting data in tables and graphs, finding slopes, means and ranges, and showing uncertainty.

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Interpreting and Evaluating Data

Spotting patterns, testing hypotheses, judging data quality, finding errors and anomalies, and suggesting improvements.

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Units and Maths Skills (1 lessons)

Explore units and maths skills in Biology.

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Units, Prefixes and Significant Figures

Scientific vocabulary, SI units, prefixes and powers of ten, unit conversions and significant figures.

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